[{"command":"openDialog","selector":"#drupal-modal","settings":null,"data":"\u003Cdiv class=\u0022isi-content mCustomScrollbar\u0022\u003E\u003Cdiv class=\u0022bosulif-isi-section\u0022\u003E\u003Cdiv class=\u0022do-nt-tak\u0022\u003EDo not take BOSULIF if you are allergic to bosutinib or any of the ingredients in BOSULIF.\u003C\/div\u003E\u003Cdiv class=\u0022isi-section-1\u0022\u003E\u003Cdiv class=\u0022isi-sub-title before-you-take\u0022\u003E\u003Cstrong\u003EBefore you take BOSULIF, tell your doctor if you:\u003C\/strong\u003E\u003C\/div\u003E\u003Cul class=\u0022isi-ul hav-list\u0022\u003E\u003Cli\u003Ehave liver problems\u003C\/li\u003E\u003Cli\u003Ehave heart problems\u003C\/li\u003E\u003Cli\u003Ehave kidney problems\u003C\/li\u003E\u003Cli\u003Ehave high blood pressure\u003C\/li\u003E\u003Cli\u003Ehave diabetes\u003C\/li\u003E\u003Cli\u003Eare pregnant or plan to become pregnant. BOSULIF can harm your unborn baby. Tell your doctor right away if you become pregnant while taking BOSULIF\u003Cul class=\u0022isi-ul isi-sub-ul\u0022\u003E\u003Cli\u003E\u003Cstrong\u003EFemales\u003C\/strong\u003E who are able to become pregnant should have a pregnancy test before starting treatment with BOSULIF and should use effective birth control (contraception) during treatment with BOSULIF and for at least 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you\u003C\/li\u003E\u003C\/ul\u003E\u003C\/li\u003E\u003Cli\u003Eare breastfeeding or plan to breastfeed. It is not known if BOSULIF passes into your breast milk or if it can harm your baby. Do not breastfeed during treatment with BOSULIF and for at least 2 weeks after the last dose\u003C\/li\u003E\u003C\/ul\u003E\u003Cp class=\u0022isi-text-1 tel-ur-doc\u0022\u003E\u003Cstrong\u003ETell your doctor about the medicines you take,\u003C\/strong\u003E including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. BOSULIF and certain other medicines can affect each other.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022isi-section-2\u0022\u003E\u003Cdiv class=\u0022isi-sub-title\u0022\u003E\u003Cstrong\u003EBOSULIF may cause serious side effects, including:\u003C\/strong\u003E\u003C\/div\u003E\u003Cul class=\u0022isi-ul stmc-prob-ul-li\u0022\u003E\u003Cli\u003E\u003Cstrong\u003EStomach problems.\u003C\/strong\u003E BOSULIF may cause stomach (abdomen) pain, nausea, diarrhea, vomiting, or blood in your stools. Get medical help right away for any stomach problems\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003ELow blood cell counts. \u003C\/strong\u003EBOSULIF may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). Your doctor should do blood tests to check your blood cell counts regularly during your treatment with BOSULIF. Call your doctor right away if you have unexpected bleeding or bruising, blood in your urine or stools, fever, or any signs of an infection\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003ELiver problems.\u003C\/strong\u003E Your doctor should do blood tests to check your liver function regularly during your treatment with BOSULIF. Call your doctor right away if your skin or the white part of your eyes turns yellow (jaundice), or you have dark \u201ctea color\u201d urine\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EHeart problems.\u003C\/strong\u003E BOSULIF may cause heart problems, including heart failure and decreased blood flow to the heart, which can lead to heart attack. Get medical help right away if you get shortness of breath, weight gain, chest pain, or swelling in your hands, ankles, or feet\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EYour body may hold too much fluid (fluid retention).\u003C\/strong\u003E Fluid may build up in the lining of your lungs, the sac around your heart, or your stomach cavity. Get medical help right away if you get any of the following symptoms during your treatment with BOSULIF:\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022isi-sub-section\u0022\u003E\u003Cul class=\u0022isi-ul isi-sub-ul\u0022\u003E\u003Cli\u003Eshortness of breath and cough\u003C\/li\u003E\u003Cli\u003Echest pain\u003C\/li\u003E\u003Cli\u003Eswelling in your hands, ankles, or feet\u003C\/li\u003E\u003Cli\u003Eswelling all over your body\u003C\/li\u003E\u003Cli\u003Eweight gain\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cul\u003E\u003Cli\u003E\u003Cstrong\u003EKidney problems.\u003C\/strong\u003E Your doctor should do tests to check your kidney function when you start treatment with BOSULIF and during your treatment. Call your doctor right away if you get any of the following symptoms during your treatment with BOSULIF:\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022isi-sub-section\u0022\u003E\u003Cul class=\u0022isi-ul isi-sub-ul\u0022\u003E\u003Cli\u003Eyou urinate more or less often than normal\u003C\/li\u003E\u003Cli\u003Eyou make a much larger or smaller amount of urine than normal\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022isi-section-3\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EThe most common side effects of BOSULIF in adults and children with CML include\u003C\/strong\u003E diarrhea, stomach (abdominal) pain, vomiting, nausea, rash, tiredness, liver problems, headache, fever, decreased appetite, respiratory tract infections (infections in nose, throat, or lungs), constipation, and changes in certain blood tests. Your doctor may do blood tests during treatment with BOSULIF to check for changes.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETell your doctor or get medical help right away if you get respiratory tract infections, loss of appetite, headache, dizziness, back pain, joint pain, rash, or itching while taking BOSULIF. These may be symptoms of a severe allergic reaction.\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EYour doctor may change your dose, temporarily stop, or\u0026nbsp;permanently stop treatment with BOSULIF if you have certain side effects.\u003C\/p\u003E\u003Cp\u003EBOSULIF may cause fertility problems in both female and male patients. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.\u003C\/p\u003E\u003Cp\u003ETell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of BOSULIF. For more information, ask your doctor or pharmacist. You may report side effects to FDA at \u003Cspan class=\u0022phone-number\u0022\u003E1-800-FDA-1088.\u003C\/span\u003E\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022isi-indications\u0022\u003E\u003Cdiv class=\u0022ind-title\u0022\u003E\u003Cstrong\u003EINDICATIONS\u003C\/strong\u003E\u003C\/div\u003E\u003Cp class=\u0022ind-text\u0022\u003EBOSULIF is a prescription medicine used to treat:\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003Eadults and children 1 year of age and older who have a certain type of leukemia called chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) who are newly diagnosed or who no longer benefit from or did not tolerate other treatment\u003C\/li\u003E\u003Cli\u003Eadults with accelerated phase (AP) or blast phase (BP) Ph+ CML who can no longer benefit from or did not tolerate other treatment\u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003EIt is not known if BOSULIF is safe and effective in children less than 1 year of age with CP Ph+ CML who are newly diagnosed or who no longer benefit from or did not tolerate other treatment or in children with AP Ph+ CML or BP Ph+ CML.\u003C\/p\u003E\u003Cdiv class=\u0022full-prescribe-links\u0022\u003EPlease see \u003Ca href=\u0022https:\/\/labeling.pfizer.com\/ShowLabeling.aspx?id=884\u0022 target=\u0022_blank\u0022\u003EPatient Information and full Prescribing Information\u003C\/a\u003E.\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E","dialogOptions":{"dialogClass":"popup-dialog-class sidebar-dialog-right","width":"90%","modal":true,"title":"IMPORTANT SAFETY INFORMATION AND INDICATIONS FOR PATIENTS","classes":{"ui-dialog":"popup-dialog-class sidebar-dialog-right"}}}]