Medication reminders
Manage all of your medications in one place and stay on top of your BOSULIF therapy with personalized reminders.
Starting Your Journey with BOSULIF is a patient support
brochure created specifically for people who are prescribed
BOSULIF. Download this brochure as your chronic myelogenous
leukemia (CML) treatment resource and learn more about what
to expect with treatment throughout therapy.
Manage all of your medications in one place and stay on top of your BOSULIF therapy with personalized reminders.
Make the most of your BOSULIF treatment with tailored articles and content. Learn more about possible side effects and build habits that can help you better manage your condition.
Log your diet and exercise habits, and track how you have been feeling since your last appointment.
Allow your friends and family to receive weekly progress updates and reminders for appointments. Download and print out your MyTherapy® health report and discuss it with your doctor at your next appointment.
If you are looking for additional support or information, you can find external
programs and networks below. Visit their websites or call directly with the phone
numbers provided.
The Cancer Support Community is an
international nonprofit dedicated to
providing support, education, and
hope to people affected by cancer.
Phone: 1-888-793-9355
An organization on the front lines of the
fight to cure blood cancer. LLS is
dedicated to research, patient access,
and policy and advocacy. It has
resources available for both patients
and caregivers to help them in their
journey with Ph+ CML.
Phone: 1-800-955-4572
The Caregiver Action Network
provides education, peer support, and
resources to family caregivers across
the United States, free of charge.
Phone: 1-202-454-3970
The Well Spouse Association advocates
for and addresses the needs of
individuals caring for a chronically ill
and/or disabled spouse/partner.
Phone: 1-732-577-8899
Learn More
About CML
When a loved one has Ph+ CML, there are many things you can do to help them through their disease and treatment. Use the information in this brochure to help them with:
You can make a difference in your loved one’s treatment
Reminders about treatment, emotional support, and accompanying your loved one when talking to healthcare professionals
(HCPs) can help make your loved one’s journey with BOSULIF easier.
Use the following reminders to help your loved ones:
What is Philadelphia chromosome–positive chronic myeloid leukemia
(Ph+ CML)?
CML can be caused by an abnormal chromosome called the Philadelphia chromosome. If your CML is caused by
this chromosome, it may also be referred to as Ph+ CML. This abnormal chromosome produces an abnormal
protein called BCR-ABL. BCR-ABL causes the bone marrow to grow and divide out of control
How does BOSULIF work?
BOSULIF is a type of drug called a protein tyrosine kinase inhibitor (TKI). BOSULIF blocks the abnormal BCR-ABL protein made by CML cells that have the Philadelphia chromosome and helps prevent the creation of
leukemia cells.
How can I track the progress of my treatment?
Frequent monitoring and blood tests are very important, so ask your doctor or healthcare professional (HCP) about getting tests that gauge the status of your disease and how you are responding to treatment.
Monitoring with quantitative polymerase chain reaction (qPCR) every 3 months is recommended for all patients after initiating therapy, including those who meet response milestones at 3, 6, and 12 months.
How often you will have these tests will be determined by your doctor or HCP. Talk to your doctor or HCP about any questions or concerns you may have about these tests.
What are the potential side effects associated with taking BOSULIF?
BOSULIF may cause a range of side effects. It’s important to be aware of the side effects so you know what may occur.
BOSULIF may cause serious side effects, including:
The most common side effects of BOSULIF in people with CML include: diarrhea, rash, nausea, stomach (abdomen) pain, vomiting, tiredness, liver problems, respiratory tract infections (infections in nose, throat, or lungs), fever, headache, and changes in certain blood tests. Your doctor may do blood tests during treatment with BOSULIF to check for changes.
Tell your doctor or get medical help right away if you get respiratory tract infections, loss of appetite, headache, dizziness, back pain, joint pain, or itching while taking BOSULIF. These may be symptoms of a severe allergic reaction.
Your doctor may change your dose, temporarily stop, or permanently stop treatment with BOSULIF if you have certain side effects.
BOSULIF may cause fertility problems in both female and male patients. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of BOSULIF. For more information, ask your doctor or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.
How should I take BOSULIF?
It is important to take BOSULIF exactly as prescribed by your doctor. Follow the instructions below and talk with your doctor or HCP for more information.
BOSULIF is taken by mouth once a day
BOSULIF should be taken with food
Swallow BOSULIF tablets whole
When you take BOSULIF...
Accelerated phaseb: The stage of chronic myelogenous leukemia (CML) when 10% to 19% of cancer cells in blood and bone marrow are blast cells.
BCR-ABL: An abnormal protein that causes the bone marrow to produce leukemia cells.
Blast phaseb: The stage of CML when 20% or more of the cells in the blood or bone marrow are blast cells.
Bone marrow: The soft, sponge-like tissue in the center of most bones. It makes white blood cells, red blood cells, and platelets.
Chromosome: Part of a cell that holds genetic information.
Chronic phaseb: The phase of CML that most patients are diagnosed in. In this phase, less than 10% of the cells in the blood or bone marrow are blast cells.
Complete hematologic response: A return of blood cells to normal levels.
Complete cytogenetic response (CCyR): When there are no cells with the Philadelphia chromosome (Ph+) in your bone marrow.
H2 blockers: Medicines that reduce the amount of stomach acid in the lining of your stomach.
Intolerance: When a patient can no longer take his or her current medicine due to side effects.
Molecular response: A decrease in the percentage of blood cells containing BCR-ABL.
Newly diagnosed: When a patient is being treated for his or her cancer for the first time.
Philadelphia chromosome: An abnormality in your chromosome that results in the production of BCR-ABL protein. This protein causes leukemia cells to grow uncontrollably.
Proton pump inhibitor: A substance used to treat certain disorders of the stomach and intestines, such as heartburn and ulcers.
Resistance: When your disease fails to respond or stops responding to a given therapy.
Severe diarrhea: Severe diarrhea is an increase of greater than or equal to 7 stools/day over baseline
or pretreatment.
Tyrosine kinase inhibitors (TKIs): In CML, a TKI is used to block the activity of BCR-ABL protein (a tyrosine kinase); this slows leukemia cell growth.
aUnless otherwise noted, the definitions above are from the National Cancer Institute (NCI) or adapted from the Leukemia & Lymphoma Society (LLS) and the National Institutes of Health (NIH).
bThe phase definitions above are from the World Health Organization (WHO). Some doctors may use different definitions. Talk to your doctor about any questions or concerns you may have about the different phases.
Make sure to tell your doctor or HCP of any changes in:
Your medicines or any new
medicines you start taking.
Side effects, including
ones
that bother you or
do not
go away.
How you are feeling,
even if you think it is not
related to your CML.
Your lifestyle, including
any new health issues
that may arise.
Start a routine
Take your medicine at the same time
every day. Consider taking BOSULIF®
(bosutinib) in the morning with breakfast
or in the evening with dinner.
Use alarms and
calendars as reminders
to take medicine.
Use a pill container to organize
your medicines at home and
when you travel.
Your doctor or HCP can help you with side effects
When you start treatment, consider
asking your doctor how to prepare for
possible episodes of diarrhea, the most
common side effect of BOSULIF.
Dose adjustments from your doctor,
lifestyle management, and monitoring over
time may help you manage side effects.